Ras and Myc can drive oncogenic cell proliferation through individual D-cyclins
نویسندگان
چکیده
منابع مشابه
Direct reprogramming by oncogenic Ras and Myc.
Genetically or epigenetically defined reprogramming is a hallmark of cancer cells. However, a causal association between genome reprogramming and cancer has not yet been conclusively established. In particular, little is known about the mechanisms that underlie metastasis of cancer, and even less is known about the identity of metastasizing cancer cells. In this study, we used a model of condit...
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(Cell 133, 78–89; April 4, 2008) Our paper reported that overexpression of tRNAi Met can promote cell proliferation and transformation. It has now become clear that images in several figures are duplications that do not represent the experiments described in the legends. Given these issueswith the validity of the figures, we believe that themost appropriate course of action is to retract the pa...
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Characteristics of transformed and tumor cells include increased levels of protein synthesis and elevated expression of RNA polymerase (pol) III products, such as tRNAs and 5S rRNA. However, whether deregulated pol III transcription contributes to transformation has been unclear. Generating cell lines expressing an inducible pol III-specific transcription factor, Brf1, allowed us to raise tRNA ...
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The discovery of oncogenes provided insight into the molecular underpinnings of cancer and suggested the promise of novel molecular strategies for cancer treatment as highlighted in this issue by Yaari et al. and by Bishop previously (1, 2). However, only recently have effective drugs that target oncogenes been successfully introduced into the clinical setting. The flagship example of a targete...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2005
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1208853